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3-oxo-1,3-dihydro-2-benzofuran-1-yl 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylate

Talniflumate

CAS: 66898-62-2

Molecular Formula: C21H13F3N2O4

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3-oxo-1,3-dihydro-2-benzofuran-1-yl 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylate - Names and Identifiers

Name Talniflumate
Synonyms ba7602-06
66898-62-2
Talniflumate
2-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinicaciphthalidylester
2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinicacidphthalidylester
3-phthalidylesterof2-((3-(trifluoromethyl)phenyl)amino)-3-pyridinecarboxyl
3-ftalidilicodelacido2-((3-(trifluormetil)fenil)amino)-3-piridincarboxilic
(3-oxo-1H-2-benzofuran-1-yl) 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate
3-Oxo-1,3-dihydro-2-benzofuran-1-yl 2-{[3-(trifluoromethyl)phenyl]amino}nicotinate
2-[3-(trifluoromethyl)anilino]-3-pyridinecarboxylic acid (3-oxo-1H-isobenzofuran-1-yl) ester
3-oxo-1,3-dihydro-2-benzofuran-1-yl 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylate
2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid 1,3-Dihydro-3-oxo-1-isobenzofuranyl Ester
3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester
CAS 66898-62-2
EINECS 1533716-785-6
InChI InChI=1/C21H13F3N2O4/c22-21(23,24)12-5-3-6-13(11-12)26-17-16(9-4-10-25-17)19(28)30-20-15-8-2-1-7-14(15)18(27)29-20/h1-11,20H,(H,25,26)

3-oxo-1,3-dihydro-2-benzofuran-1-yl 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylate - Physico-chemical Properties

Molecular FormulaC21H13F3N2O4
Molar Mass414.33
Density1.49±0.1 g/cm3(Predicted)
Melting Point165-167°C
Boling Point534.6±50.0 °C(Predicted)
Flash Point277.1°C
Solubility Chlorform (Slightly), DMSO (Slightly), Methanol (Slightly)
Vapor Presure1.67E-11mmHg at 25°C
AppearanceSolid
ColorOff-White to Pale Yellow
Maximum wavelength(λmax)['287nm(CHCl3)(lit.)']
Merck14,9044
pKa2.72±0.10(Predicted)
Storage ConditionStore at +4°C
StabilityAcid Sensitive, Moisture Sensitive
Refractive Index1.625
Physical and Chemical PropertiesWhite to pale yellow crystalline powder.
UseAs a non-steroidal anti-inflammatory analgesic, it can be used for the adjuvant treatment of fibrous cyst and asthma

3-oxo-1,3-dihydro-2-benzofuran-1-yl 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylate - Risk and Safety

RTECSQT2999200
ToxicityLD50 orally in rats: 12000 mg/kg (Los)

3-oxo-1,3-dihydro-2-benzofuran-1-yl 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylate - Reference Information

biological activity Talniflumate (MSI-1995) is an anti-inflammatory agent in the treatment of cystic fibrosis, it is used as a mucin modulator in chronic obstructive pulmonary disease and asthma. Talniflumate is also a human Calcium-activated chloride channel.
Target IC50: Ca 2 -activated Cl-channel (CaCC)
Animal Model: CF mice with distal intestinal obstructive syndrome (DIOS)
Dosage: 0.4 mg/g
Administration: Oral chow; 21 days
Result: Increased survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.
Use Tamoxifen is a non-steroidal anti-inflammatory and analgesic drug substance, and can be used for the adjuvant treatment of fibrous cysts and asthma.
Last Update：2024-04-10 22:29:15
3-oxo-1,3-dihydro-2-benzofuran-1-yl 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylate
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CAS: 66898-62-2
Tel: +86-18821248368
Email: Int06@meryer.com
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CAS: 66898-62-2
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CAS: 66898-62-2
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Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Talniflumate Visit Supplier Webpage Request for quotation
CAS: 66898-62-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Shaanxi Baoxin Pharmaceutical Co.,Ltd
Product Name: Talniflumate Request for quotation
CAS: 66898-62-2
Tel: 0086-571-88899366
Email: info@sxbxpharm.com
Mobile: 15167562001
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View History
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